Recently, Associate Professor Liu Bin from the team of Professor Wang Lei of College of Materials and Materials has made important progress in the field of domestic chemical blood test devices. The research results were published in the top academic journal "Angew. Chem. Int. Ed." (JCR Q1, Impact Factor: 12.102) ). The title of the paper is Paper-based ratiometric fluorescence analytical devices towards point-of-care testing of human serum albumin, Shenzhen University is the first author and corresponding author of this paper.

Monitoring of human serum albumin (HSA) in a point-of-care fashion is urgently needed in particular for elderly or chronically ill patients. Herein, a dual-state emissive chalcone probe having the feature of aggregation-induced emission was designed and synthesized. The concentration of HSA can be evaluated by the ratios of emission from probes in aggregated and monomeric state, which gives a visually discernible red-to-green color change. A simple, portable paper-based analytical device have been fabricated by integration of the recognition probe in the detection pad and employed for HSA test using the whole blood samples. This paper-based assay shows the analytical capability comparable to the standard testing methods but is in a point-of-care fashion, providing a promising tool for at-home HSA detection and HSA-related disease diagnosis.

Paper-based ratiometric fluorescence analytical devices towards point-of-care testing of human serum albumin,DOI: 10.1002/anie.201915046